Preimplantation Genetic Tests PGD/PGS

PGD/PGT is a technique used in reproductive medicine to test for genetic abnormalities in the embryo before implantation into the uterus after in-vitro fertilization. The genetic abnormalities in the embryo are broadly classified into two types one at the chromosome level and the other at the gene level. Based on the genetic abnormality the PGT is again classified into three different types.

PGT-A: PGT-A is used to check for the aneuploidy status of the chromosomes in the embryo. PGT-A is used to avoid the chance of having a child with missing or an extra number of chromosomes.

PGT-SR: Parents with balanced translocations can produce embryos with unbalanced translocations or loss of genetic material leading to unsuccessful pregnancy. PGT-SR is a genetic test used to check for chromosomal rearrangements like unbalanced translocations/inversions in embryos that can lead to pregnancy loss.

PGT-M: PGT-M refers to PGT done for monogenic disorders. PGT-M is generally used to test an embryo that is suspected to have a particular genetic condition like single mutations. The particular genetic disease is already known in the families who are seeking for IVF technologies. PGT-M is mostly useful for the couple who are known to be carriers for a particular single gene disorder like thalassemia, cystic fibrosis, etc.

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